Publications

2025

• DM. Ghetu, K. Raymond, I. Titorencu, M. Simionescu, Innovative Strategies: Use of Stromal Cell-Derived Secretome for Chronic Wound Therapy, IJMS, 26:12, 2025. (IF/2024=4.9)
• I. Luca, MG. Albu Kaya, R. Țuțuianu, CE. Dinu-Pîrvu, MM. Marin, L. Popa, I. Titorencu, V. Anuța, MV. Ghica, Effect of Gellan Gum on the Properties of Collagen-HPMC Freeze-Dried Hydrogels for Mucosal Administration. Gels. 11(10):793, 2025. (IF/2025=5.3)
• BV. Sorca, DA. Kaya, MG. Albu Kaya, M. Enachescu, D-M. Ghetu, L-B. Enache, I. Boerasu, AE. Coman, LC. Rusu, R. Constantinescu, I. Titorencu. Bone Fillers with Balance Between Biocompatibility and Antimicrobial Properties, Biomimetics 10(2):100, 2025.(IF/2024=3.9)
• AF. Vladu, MG. Albu Kaya, A. Ficai, D. Ficai, R. Țuțuianu, L. Motelica, VA. Surdu, OC. Oprea, RD. Truşcă, I. Titorencu, Localized Combination Therapy Using Collagen–Hydroxyapatite Bone Grafts for Simultaneous Bone Cancer Inhibition and Tissue Regeneration. Polymers 17(16), 2239, 2025. (IF/2024=4.9)
• AE. Coman, MM. Marin, AM. Rosca, R. Țuțuianu, MG. Albu Kaya, A. Ionita, RR. Constantinescu, I. Titorencu, Comparative Study of Collagen Gels Extracted from Different Sources. Gels 11(11):879, 2025. (IF/2025=5.3)
• I. Luca, MG. Albu Kaya, I. Titorencu, CE. Dinu-Pîrvu, MM. Marin, L. Popa, AM. Rosca, A. Antoniac, V. Anuta, RM. Prisada, et al. Influence of Mucoadhesive Polymers on Physicochemical Features and Biocompatibility of Collagen Wafers, ACS Polym Au. 5:3, 282–297, 2025. (IF/2024=6.9)
• BV. Sorca, AM. Rosca, DA. Kaya, SM. Vatamanu, MG. Albu Kaya, AE. Coman, LC. Rusu, I. Titorencu, Composites based on collagen, chondroitin sulfate, and sage oil with potential use in dentistry. Biomimetics, 2025 (IF/2024=3.9), in press

2024

• DM. Vranceanu, E. Ungureanu, IC. Ionescu, AC. Parau, V. Pruna, I. Titorencu, M. Badea, C-Ș. Gălbău, M. Idomir, M. Dinu, et al. In Vitro Characterization of Hydroxyapatite-Based Coatings Doped with Mg or Zn Electrochemically Deposited on Nanostructured Titanium. Biomimetics 9, 244, 2024. (IF/2023=3.4)
• F. Popescu, I. Titorencu, M. Albu Kaya, F. Miculescu, R. Tutuianu, AE. Coman, E. Danila, MM. Marin, D-L. Ancuta, C. Coman, et al. Development of Innovative Biocomposites with Collagen, Keratin and Hydroxyapatite for Bone Tissue Engineering. Biomimetics 9, 428. 2024. (IF/2023=3.4)

2023

• Luca, M. G. Albu Kay, I. Titorencu, CE. Dinu-Pîrvu, MM. Marin, L. Popa, A-M. Roșca, A. Antoniac, V. Anuța, MV. Ghica, Design and Evaluation of New Wound Dressings based on Collagen-Cellulose Derivatives, Materials and Design 236, 112469, 2023. (IF/2023=7.6)

2022

• DM Iacomi (Ghetu), AM Rosca, R Tutuianu, TP Neagu, V Pruna, M Simionescu, I Titorencu. Generation of an immortalized human adipose-derived mesenchymal stromal cell line suitable for wound healing therapy. Int J Mol Sci. 23: 8925, 2022. (IF/2022=5.6)
• E. Dănilă, R. Stan, MA. Kaya, G. Voicu, MM. Marin, A. Moroşan, I. Titorencu, R. Ţuţuianu, Valorization of Cyprinus Carpio skin for biocompatible collagen hydrolysates with potential application in foods, cosmetics and pharmaceuticals, Waste Biomass Valor, 13: 917-928, 2022. (IF/2022=3.2)

2021

• R. Tutuianu, A-M. Rosca, MD. Iacomi, M. Simionescu, I. Titorencu, Human mesenchymal stromal cell-derived exosomes promote in vitro wound healing by modulating the biological properties of skin keratinocytes and fibroblasts and stimulating angiogenesis, IJMS, 22,6239, 2021. (IF/2023=6.208)
• Micheu MM, Rosca AM, Patient-specific induced pluripotent stem cells as "disease-in-a-dish" models for inherited cardiomyopathies and channelopathies - 15 years of research. World J Stem Cells, 26;13(4):281-303, 2021. (IF/2021=3.124)

2019

• R. Ţuţuianu, AM. Roşca, G. Florea, V. Prună, DM. Iacomi, LA. Rădulescu, TP. Neagu, I. Lascăr, I. Titorencu, Heterogeneity of human fibroblasts isolated from hypertrophic scar, Romanian Journal of Morphology and Embryology, 60(3):793-802, 2019. (IF/2019=1.411)
• A.Vladescu, V. Pruna, S. Kulesza, V. Braic, I. Titorencu, M. Bramowicz, A. Gozdziejewska, A. Parau, C. M.Cotrut, I. Pana, M. Dinu, M. Braic, Influence of Ti, Zr or Nb carbide adhesion layers on the adhesion, corrosion resistance and cell proliferation of titania doped hydroxyapatite to the Ti6Al4V alloy substrate, utilizable for orthopaedic implants, Ceramics International 45(2)A: 1710-1723, 2019. (IF/2019=3.830)
• Mocioiu, Ana Maria; Tutuianu, Raluca; Cursaru, Laura Madalina; Piticescu, Roxana Mioara; Stanciu, Paul; Vasile, Bogdan Stefan; Trusca, Roxana; Sereanu, Viviana; Meghea, Aurelia, 3D structures of hydroxyapatite obtained from Rapana venosa shells using hydrothermal synthesis followed by 3D printing, Journal of Materials Science 54( 22):13901, 2019. (IF/2019=3.553)

Book chapters

• A-M Rosca, R. Tutuianu, I. Titorencu, Advances in Skin Regeneration and Reconstruction. In book: Frontiers in stem cells and regenerative medicine research Vol. 9, Ed. Atta-ur- Rahman and Shazia Adjum, 143-187, Bentham Science Publishers LTD, ISBN: 978-1-68108-436-7, 2020.
• M. Dinu, S. Franchi, V. Prună, C. M. Cotruț, V. Secchi, M. Santi, I. Titorencu, C. Battocchio, G. Iucci, A. Vlădescu, Ti-Nb-Zr system and its surface biofunctionalization for biomedical applications. „Titanium for Medical and Dental Applications - A review of all aspects of titanium use in the medical and dental industries”, Ed. F. Froes, M. Qian, Elsevier, ISBN 9780128124567, 2018.
• N. Alexandru, I. Titorencu, S. Frunzã, E. Bãdilã, A. Georgescu, Endothelial Progenitor Cell Dysfunction In The Pathogenesis Of Vascular Complications Of Diabetes, “Advances in biochemistry in health and disease”, Ed C.C. Kartha, S. Ramachandran, M Radhakrishna Pillai, Springer, ISBN 978-3-319-60323-0, p.159-208, 2017.
• Titorencu, V. Pruna, VV. Jinga, M. Simionescu, Bone replacement therapy. Advanced biocompatible structures for prospective bioengineering: Concepts and Strategies, Ed: M. Costache, M. Simionescu, The Publishing House of the Romanian Academy, ISBN 978-973-27-2317-3, 2013.
• MG. Albu, I.Titorencu, MV. Ghica, “Collagen-based Drug Delivery Systems for Tissue Engineering” in book: Biomaterials Applications for Nanomedicine, InTech, ISBN 978-953-307-661-4, 2011.
• I.Titorencu, MG. Albu, V. Jinga. The future of cardiovascular medicine: Biomaterials for tissue therapy. In book: From Vascular Cell Biology to Cardiovascular Medicine, Ed: Adriana Georgescu, Felicia Antohe, published by RESEARCH SIGNPOST TRANSWORLD RESEARCH NETWORK, ISBN - 978-81-7895-503-2, 2011.

Awards

• PhD Student Daniela-Madalina Ghetu - L’Oréal UNESCO National Fellowship for Women in Science, 15^th Edition, “Life Sciences” Section, 2024-2025.
• D.M. Vranceanu, I.D. Titorencu, A. Vladescu (Dragomir), E. Ungureanu, V. Pruna, A.C. Parau, C.M. Cotrut, Gold Medal and Special Prize offered by „Lucian Blaga” University Sibiu for patent application no. A/00760/28.11.2023 at 10^th Edition of International Exhibition of Inventions and Innovations “Traian Vuia”, Timisoara, Romania, 13 – 15 Iune 2024.
• Gold Medal for presentation “Optimization of human mesenchymal stem cells interaction with innovative biomimetic structures for tissue engineering applications”, A. Vladescu, A.C. Parau, I. Titorencu, V. Pruna, C. M. Cotrut, D. M. Vranceanu, Proiect no. 621PED/2022, (registration cod PN-III-P2-2.1-PED-2021-4275) International Exhibition INVENTCOR, 4th Edition, Deva, Romania, 14 -16 September 2023.
• Alina Vladescu, Anca C. Parau, Irina Titorencu, Vasile Pruna, Cosmin M. Cotrut, Diana M. Vranceanu, Silver Medal for presentation: “Optimization of human mesenchymal stem cells interaction with innovative biomimetic structures for tissue engineering applications” at 9^th Edition of International Exhibition of Inventions and Innovations “Traian Vuia”, Timisoara, Romania, 15-17 Mai 2023.
• Dr. Raluca Tutuianu - L’Oréal UNESCO National Fellowship for Women in Science, 13^th Edition, “Life Sciences” Section, 2022.
• Albu Kaya MG, Lascar I, Stancu IC, Titorencu ID, Zamfirescu DG, Zegrea I, Marin S, Lungu A, Tutuianu R, Simionescu M., Gold Medal and Special Prize at 7^th Edition of International Exhibition of Inventions and Innovations “Traian Vuia”, for patent „Porous stratified scaffolds for the personalized treatment of difficult wounds and process for preparing the same”, Timisoara, Romania, 8-10 Octomber 2022.
• Albu M. G., Lascar I., Zamfirescu D. G., Simionescu M., Zegrea I., Titorencu I., Popescu M., Bumbeneci G., Gold Medal for patent application „Nervous conductors made of collagen and process for preparing the same”, , EUREKA, Brussels, 2013.
• Albu M. G., Lascar I., Zamfirescu D. G., Simionescu M., Zegrea I., Titorencu I., Popescu M., Bumbeneci G., AGEPI Prize (Agence d’État pour la Propriété Intellectuelle,) for: „Nervous conductors made of collagen and process for preparing the same”, 62^nd edition of the International Invention, Research and New Technology Fair - INNOVA, Brussels, 2013.

Patents

• Patent application (OSIM) A/00760/28.11.2023, Vranceanu D.M., Titorencu I.D., Vladescu A. (Dragomir), Ungureanu E., Pruna V., Parau A.C., Cotrut C.M, “Acoperire biomimetica pe baza de ceramica bioactiva pentru dispozitive medicale implantabile din titan”.

• Patent application (OSIM) A/00370/26.06.2021 2021 Simionescu M., Titorencu I., Rosca AM, Pruna V., Tutuianu R., Ghetu MD, Lascar I., Neagu T. P., Mogoanta L., Checherita I.A., Mogosanu G.D., Pirici N.D., Streba C.T., Barca A.C., Burdusel A.C., Stoica A.E., Grumezescu A.M., Chircov C., „Composite polymeric hydrogels with antibacterial and healing properties and process for obtaining them”.

• BOPI nr. 6/2021: Vladescu A, Cotruț CM, Kiss AE, Braic M, Titorencu I, Braic V, „Thin inorganic bioactive osteoconductive layers based on hydroxyapatite deposited on magnesium alloy substrate”.

• BOPI nr. 3/2019: Albu MG, Lascăr I, Stancu IC, Titorencu I, Zamfirescu DG, Zegrea I, Marin S, Lungu A, Nitipir C, Țuțuianu R, Simionescu M, “Porous stratified scaffolds for the personalized treatment of difficult wounds and process for preparing the same”.

• BOPI nr. 12/2012: Albu M. G., Lascar I, Zamfirescu DG, Simionescu M, Zegrea I, Titorencu I, Popescu M, Bumbeneci G, “Nervous conductors made of collagen and process for preparing the same”.

Main International Colaborations

Leiden University Medical Center, Anatomy and Embryology Department, Leiden, the Netherlands Dr. Karine Raymond

Main National Colaborations

• National University of Science and Technology Politehnica Bucharest

• National Research and Development Institute for Textiles and Leather Bucharest

• National Institute of Research and Development for Optoelectronics - INOE 2000

• Central Military Emergency University Hospital "Dr. Carol Davila"

• Zetta Hospital

• Emergency Clinical Hospital Bucharest

• Lascar Clinic

• University of Medicine and Pharmacy Craiova

• “Carol Davila” University of Medicine and Pharmacy

National Projects/ Proiecte Naționale

Stem cells, biomaterials and bone regeneration

2022-2024: Optimization of human mesenchymal stem cells interaction with innovative biomimetic structures for tissue engineering applications, PN-III-P2-2.1-PED-2021-4275, 2022-2024

2018-2020: Bioactive nanostructures for innovative therapeutic strategies, PN-III-P1-1.2-PCCDI-2017-0749

2014-2016 Biodegradable Implants from Magnesium Alloys used in Foot and Ankle Surgery, PN-II-PT-PCCA-2013-4-2267

2014-2016 Multifunctional coatings for load bearing implants made of a novel titanium-based alloy, PN-II-PT-PCCA-2013-4-1958

Stem cells and skin regeneration

2022-2024: Enhancing the paracrine properties of fibroblasts by three-dimensional aggregation for chronic wounds therapy, PN-III-P1-1.1-TE-2021-1344

2018-2020: Mesenchymal stromal cells contribution to the re-epithelialization process of the biomimetic skin cultures by differentiation and paracrine factors, PN-III-P1-1.1-TE-2016-1592

2014-2016 Rational design and synthesis of smart bioactive scaffolds for personalized treatment of acute and chronic cutaneous wounds, PN-II-PT-PCCA-2013-4-0816

Stem cells and cardiovascular regeneration

2010-2012 The interrelation of human osteoprogenitor cells with human endothelial cells studied in vitro on bicameral models and three-dimensional supports; initiation and promotion of angiogenesis, PN-II-RU-PD-2010-1

2007-2008 In vitro effect of the ischemic myocardium released factors in the cardiomyocyte differentiation of adult stem cells, CNCSIS TD 371

International Projects & Grants/ Proiecte & Granturi Internașionale

2023-2026 Enhancing the endogenous anti-oxidant and cholesterol removal potential by gene editing in fatty liver disease; pre-clinical studies, Prof. Shlomo Sasson, Hebrew University, Jerusalem, Israel

2022-2026: COST Action CA21108, European Network for Skin Engineering and Modeling, Chair of the Action: Sandrine DUBRAC (AU)

2016-2021: COST Action CA16119 CellFit, “In vitro 3-D total cell guidance and fitness”, Chair of the Action: Prof Tiziana BREVINI (IT)

2010-2013: RAMSES FP7 - Research Potential REGPOT-2009-2: RAMSES: Reinforcement of the Adult stem cell research area through Mobility and Scientific networking between Egypt, Romania and a German consortium for Strengthening the international scientific competency. Grant agreement no. 245691, scientific coordinator for IBPC “N. Simionescu”: Dr. Marilena Lupu