Publicatii

List of Published Papers in the last ten years (ISI journals with impact factor)

2026

  1. Voicu G, C. A. Mocanu, F. Safciuc, …., Calin M, “Precision RNA interference of Smad3 and Runx2 via dual targeting nanocarriers mitigates aortic valve disease” J Transl Med. 2026 Jan 10. doi: 10.1186/s12967-026-07686-1.

2025

  1. Turtoi M, Deleanu M, Anghelache M, Voicu G, Anton R, Safciuc F, M Calin, Targeting Insulin Resistance in Hepatocytes: A Novel Insulin-Mimetic Agent Delivered via an Advanced Nanocarrier System, ACS Pharmacology & Translational Science, 2025, https://doi.org/10.1021/acsptsci.5c00483

  2. Voicu G, C. A. Mocanu, F. Safciuc, …., Calin M, “Nanocarrier-Driven Dual Targeting VCAM-1/Collagen IV Enables RNA Interference-Mediated Silencing of Smad3 and Runx2 to Mitigate Aortic Valve Disease,” bioRxiv, (2025), 2025.07.31.668019, https://doi.org/10.1101/2025.07.31. 668019v1.

  3. Anghelache M, Voicu G, Anton R, Safciuc F, Boteanu D, Deleanu M, Turtoi M, Simionescu M, Manduteanu I, Calin M, Inflammation resolution-based treatment of atherosclerosis using biomimetic nanocarriers loaded with specialized pro-resolving lipid mediators, Materials Today Bio, Volume 32, June 2025, 10.1016/j.mtbio.2025.101733.

  4. Motelica L, Voicu G, Chircov C, Surdu VA, Trusca R, Vasile B, Ficai D, Oprea OC, Marta DS, Peteu VE, Anghelache M, Gherghiceanu M, Ficai A, Calin M, Aspartic acid-functionalized magnetic nanoparticles for enhanced internalization in tumoral cells. Journal of the Australian Ceramic Society, 2025, DOI 10.1007/s41779-024-01102-x.

2024

  1. Voicu G., Mocanu C.A., Safciuc F.,…., Calin M, VCAM-1 targeted nanocarriers of shRNA-Smad3 mitigate endothelial-to-mesenchymal transition triggered by high glucose concentrations and osteogenic factors in valvular endothelial cells, International Journal of Biological Macromolecules (2024), https://doi.org/10.1016/ j.ijbiomac.2024.136355 IF: 7.7

  2. Anghelache M,Voicu G, Deleanu M, Turtoi M, Safciuc F, Anton R, Boteanu D, Fenyo IM, Manduteanu I, Simionescu M, Calin M, Biomimetic Nanocarriers of Pro-Resolving Lipid Mediators for Resolution of Inflammation in Atherosclerosis, Adv Healthc Mater, 2024 Jan;13(3):e2302238. doi: 10.1002/adhm.202302238. IF: 11.092

  3. Brebu M, Pamfil D, Stoica I, Aflori M, Voicu G, Stoleru E. Photo-crosslinked chitosan-gelatin xerogel-like coating onto "cold" plasma functionalized poly(lactic acid) film as cell culture support. Carbohydr Polym. 2024 Sep 1;339: 122288. doi: 10.1016/j.carbpol.2024.122288. Epub 2024 May 17, IF: 11.2.

2023

  1. Varna, M.*; Calin, M.*; Gebeshuber, I.C.*, Advances in Natural and Bio-Inspired Nanoparticles for the Treatment of Cardiovascular Diseases. Nanomaterials 2023, 13, 3015.https://doi.org/10.3390/nano13233015 IF: 5.719

  2. Pelin IM, Popescu I, Calin M, Rebleanu D, Voicu G, Ionita D, Zaharia MM, Constantin M, Fundueanu G. Tri-Component Hydrogel as Template for Nanocrystalline Hydroxyapatite Deposition Using Alternate Soaking Method for Bone Tissue Engineering Applications. Gels. 2023 Nov 16;9(11):905. doi: 10.3390/gels9110905. IF: 4.6

  3. Voicu G, Cristina Ana Mocanu, Florentina Safciuc, Maria Anghelache, Mariana Deleanu, Sergiu Cecoltan, Mariana Pinteala, Cristina Mariana Uritu, Ionel Droc, Maya Simionescu, Ileana Manduteanu, Calin M, Nanocarriers of shRNA-Runx2 directed to collagen IV as a nanotherapeutic system to target calcific aortic valve disease, Materials Today Bio, 100620, 2023, IF: 10.761

  4. Craciun BF, Clima L, Bostiog DI, Silion M, Calin M, Peptanariu D, Pinteala M, Multilayer gold nanoparticles as non-viral vectors for targeting MCF - 7 cancer cells, Biomaterials Advances, 2023, 144, 213201, IF 8.457

2022

  1. Movileanu C, Anghelache M, Turtoi M, Voicu G, Neacsu IA, Ficai D, Trusca R, Oprea O, Ficai A, Andronescu E, Calin M. Folic acid-decorated PEGylated magnetite nanoparticles as efficient drug carriers to tumor cells overexpressing folic acid receptor, Int J Pharm. 2022 Aug 8;625:122064. doi: 10.1016/j.ijpharm.2022.122064, IF 6.510

  2. Turtoi, M.; Anghelache, M.; Patrascu, A.A.; Deleanu, M.; Voicu, G.; Raduca, M.; Safciuc, F.; Manduteanu, I.; Calin, M.; Popescu, D.-L. Antitumor Properties of a New Macrocyclic Tetranuclear Oxidovanadium(V) Complex with 3-Methoxysalicylidenvaline Ligand. Biomedicines 2022, 10, 1217. https://doi.org/10.3390/biomedicines10061217, IF 6.081

  3. Fundueanu, G.; Constantin, M.; Turtoi, M.; Bucatariu, S.-M.; Cosman, B.; Anghelache, M.; Voicu, G.; Calin, M. Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells. Pharmaceutics 2022, 14, 865. https://doi.org/10.3390/pharmaceutics14040865, IF 6.525

  4. Voicu, G.; Rebleanu, D.; Mocanu, C.A.; Tanko, G.; Droc, I.; Uritu, C.M.; Pinteala, M.; Manduteanu, I.; Simionescu, M.; Calin, M. VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment. Int. J. Mol. Sci. 2022, 23, 3824. https://doi.org/10.3390/ijms23073824. IF 6.208

  5. Zaltariov M, Turtoi M, Peptanariu D, Macsim AM, Clima L, Cojocariu C, Vornicu N, Ciubotaru BI, Bargan A, Calin M, Cazacu M, Chemical Attachment of 5-Nitrosalicylaldimine Motif to Silatrane Resulting in an Organic-Inorganic Structure with High Medicinal Significance, Pharmaceutics 2022, 14(12), 2838; https://doi.org/10.3390/pharmaceutics14122838, IF 6.525

2021

  1. Popescu I, Lupei M, Constantin M, Voicu G, Calin M, Prisacaru AI, Fundueanu G, Double cross-linked pectin beads stable in physiological environment as potential support for biomedical applications, Journal of Polymer Research volume 28, Article number: 424 (2021) IF 3.097

  2. Mocanu CA, Fuior EV, Voicu G, Rebleanu D, Safciuc F, Deleanu M, Fenyo IM, Virginie Escriou V, Manduteanu I, Simionescu M, Calin M, P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation, J Control Rel, 2021, 338: pp. 754–772. https://doi.org/10.1016/j.jconrel.2021.09.012, IF 11.467

  3. Anghelache M, Turtoi M, Petrovici AR, Fifere A, Pinteala M,Calin M, Development of Dextran-Coated Magnetic Nanoparticles Loaded with Protocatechuic Acid for Vascular Inflammation Therapy, Pharmaceutics 2021, 13, 1414. https://doi.org/10.3390/pharmaceutics13091414, IF 6,525

  4. Popescu I, Lupei M, Constantin M, Voicu G, Calin M, Prisacaru AI, Fundueanu G, Double cross-linked pectin beads stable in physiological environment as potential support for biomedical applications, J Polymer Res. 2021, IF 3,097

  5. Turtoi M, Anghelache M, Bucatariu SM, Deleanu M, Voicu G, Safciuc F, Manduteanu I, Fundueanu G, Simionescu M, Calin M*, A novel platform for drug testing: Biomimetic three-dimensional hyaluronic acid-based scaffold seeded with human hepatocarcinoma cells. Int J Biol Macromol. 2021; 185:604-619. doi: 10.1016/j.ijbiomac.2021.06.174. IF 6,953

  6. Turtoi M, Anghelache M, Patrascu AA, Maxim C, Manduteanu I, Calin M, Popescu DL, Synthesis, Characterization, and In Vitro Insulin-Mimetic Activity Evaluation of Valine Schiff Base Coordination Compounds of Oxidovanadium(V). Biomedicines. 2021 May 17;9(5):562. doi: 10.3390/biomedicines9050562. IF 6,081

  7. Manea SA, Vlad ML, Rebleanu D, Lazar AG, Fenyo IM, Calin M, Simionescu M, Manea A, Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe., Oxid Med Cell Longev. 2021 Mar 9;2021: 6685612. doi: 10.1155/2021/6685612. IF 7.310

  8. Popescu I, Turtoi M, Suflet DM, Dinu MV, Darie-Nita RN, Anghelache M, Calin M, Constantin M, Alginate/poloxamer hydrogel obtained by thiol-acrylate photopolymerization for the alleviation of the inflammatory response of human keratinocytes, Int J Biol Macromol. 2021 Mar 16;180: 418-431. doi: 10.1016/j.ijbiomac.2021.03.082 IF 8.025

2020

  1. Bucatariu S., Constantin M., Varganici C.D., Rusu D., Nicolescu A., Prisacaru I., Carnuta M., Anghelache M., Calin M., Ascenzi P., Fundueanu G. A new sponge-type hydrogel based on hyaluronic acid and poly(methylvinylether-alt-maleic acid) as a 3D platform for tumor cell growth, Int J Biol Macromol. 2020, 165: 2528–2540. IF 6.78

  2. Fuior E.V.; Mocanu C.A.; Deleanu M.; Voicu G.; Anghelache M.; Rebleanu D.; Simionescu M.; Calin M*. Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation. Pharmaceutics 2020, 12, 1066. https://doi.org/10.3390/pharmaceutics12111066. IF 6.321

  3. Voicu G, Rebleanu D, Constantinescu CA, Fuior EV, Ciortan L, Droc I, Uritu CM, Pinteala M, Manduteanu I, Simionescu M, Calin M*, Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells. Pharmaceutics. 2020 Jun 2;12(6):E507. doi: 10.3390/pharmaceutics12060507 IF 6.321

  4. Constantin M, Bucatariu S, …, Anghelache M, Fundueanu G, Pullulan derivative with cationic and hydrophobic moieties as an appropriate macromolecule in the synthesis of nanoparticles for drug delivery, International Journal of Biological Macromolecules, 2020, 164, pp. 4487–4498, https://doi.org/10.1016/j.ijbiomac.2020.09.064, IF 8.025

2019

  1. Fuior EV, Deleanu M, Constantinescu CA, Rebleanu D, Voicu G, Simionescu M, Calin M*, Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation, Pharmaceutics. 2019 Aug 3;11(8). pii: E391. doi: 10.3390/pharmaceutics11080391. IF 6.321

  2. Rebleanu D, Gaidau C, Voicu G, Constantinescu CA, Mansilla Sánchez C, Rojas TC, Carvalho S, Calin M*. The impact of photocatalytic Ag/TiO2 and Ag/N-TiO2 nanoparticles on human keratinocytes and epithelial lung cells. Toxicology. 2019 Jan 31. pii: S0300-483X(18)30225-7. doi: 10.1016/j.tox.2019.01.013. IF 4.571

  3. Constantinescu CA, Fuior EV, Rebleanu D, Deleanu M, Simion V, Voicu G, Escriou V, Manduteanu I, Simionescu M, Calin M*. Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells. Pharmaceutics. 2019 Jan 21;11(1). pii: E47. doi:10.3390/pharmaceutics11010047. IF 4.473

2018

  1. David G, Clima L, Calin M, Constantinescu CA, Balan-Porcarasu M, Uritu CM, Simionescu BC, Squalene/polyethylenimine based non-viral vectors: Synthesis and use in systems for sustained gene release, Polymer Chemistry, 9 1072-1081, 2018 IF 4.790

  1. Tucureanu MM, Rebleanu D, Constantinescu CA, Deleanu M, Voicu G, Butoi E, Calin M, Ileana Manduteanu, Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of Gi-protein inhibitor, Int J Nanomedicine. 2018;13:63-76. IF 4.60

2017

  1. A. I. Dascalu, R. Ardeleanu, A. Neamtu, S. S. Maier, C. M. Uritu, A. Nicolescu, M. Silion, D. Peptanariu, M. Calin, M. Pinteala,Transfection-capable polycationic nanovectors which include PEGylated-cyclodextrin structural units: a new synthesis pathway, J. Mater. Chem. B, 2017,5, 7164-7174; DOI:10.1039/C7TB01722G

  2. Simionescu BC, Drobota M, Timpu D, Vasiliu T, Constantinescu CA, Rebleanu D, Calin M, David G*, Biopolymers/poly(ε-caprolactone)/polyethylenimine functionalized nano-hydroxyapatite hybrid cryogel: Synthesis, characterization and application in gene delivery, Materials Science and Engineering: C (2017), 81: 167-176.

  3. Calin M, Manduteanu I, Emerging Nanocarriers-Based Approaches To Diagnose And Reduce Vascular Inflammation In Atherosclerosis, Current Medicinal Chemistry 2017;24(6):550-567.

2016

  1. Simion V, Constantinescu CA, Stan D, Deleanu M, Tucureanu MM, Butoi E, Manduteanu I, Simionescu M, Calin M, P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation, Mediators Inflamm. 2016; 2016:1625149. Epub 2016 Sep 14.

  2. Tucureanu MM, Butoi E, Gan AM, Daniela Stan, Constantinescu CA, Calin M, Simionescu M, Manduteanu I, Amendment of the cytokine profile in macrophages after their interaction with smooth muscle cells: Differential modulation by fractalkine and resistin, Cytokine, 2016, 83: 250–261,

  3. Butoi E, Gan AM, Tucureanu MM, Stan D, Macarie RD, Constantinescu C, Calin M, Simionescu M, Manduteanu I, Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis, Biochim Biophys Acta. 2016 Apr 7; 1863(7 Pt A):1568-1578. doi: 10.1016/j.bbamcr.2016.04.001

  4. Simion V, Stan D, Constantinescu C A, Deleanu M, Dragan E, Tucureanu MM, Gan AM, Butoi E, Constantin A, Manduteanu I, Simionescu M, Calin M, Conjugation of curcumin-loaded lipid nanoemulsions with cell-penetrating peptides increases their cellular uptake and enhances the anti-inflammatory effects in endothelial cells. J Pharm Pharmacol. 2016 Feb;68(2):195-207

2015

  1. Roblek M, Calin M, Schlesinger M, Stan D, Zeisig R, Simionescu M, Bendas G, Borsig L,Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis, J Control Release. 2015 Oct 30;220(Pt A):341-347. doi: 10.1016/j.jconrel.2015.10.055.

  2. Marin L, Ailincai D, CalinM, Stan D, Constantinescu CA, Ursu L, DorofteiF, PintealaM, SimionescuBC, Barboiu M, Dynameric Frameworks for DNA transfection, ACS Biomater. Sci. Eng., 2016, 2 (1), pp 104–111, DOI: 10.1021/acsbiomaterials.5b00423

  3. Uritu CM, Calin M, Maier SS, Cojocaru C, Nicolescu A, Peptanariu D, Constantinescu CA, Stan D, Barboiu M, Pinteala M, Flexible cyclic siloxane core enhances the transfection efficiency of polyethylenimine-based non-viral gene vectors, J. Mater. Chem. B, J. Mater. Chem. B, 2015, 3: 8250-8267, DOI:10.1039/c5tb01342a.

  4. Schlesinger M, Zeisig R, Ortmann K, Calin M, Gerber U, Roblek M, Borsig L, Bendas G, Inhibition of chemokine receptor CCR2 reduces sarcoma cell transendothelial migration and metastasis to the lungs, Int J Clin Pharmacol Ther. 2015 Dec;53(12):1046-1048.DOI: 0.5414/CPXCES14EA04

  5. Uritu CM, Varganici C., Ursu L, Coroaba A, Nicolescu A, Dascalu AI, Peptanariu D, Stan D,. Constantinescu CA, Simion V, Calin M, Maier SS, Pinteala M, Barboiu M, Hybrid Fullerene Conjugates as Vectors for DNA Cell-Delivery, J. Mater. Chem. B. 3 (2015) 2433-2446

  6. Calin M*, Stan D, Schlesinger M, Simion V, Deleanu M, Ana Constantinescu C, Gan AM, Pirvulescu MM, Butoi E, Manduteanu I, Bota M, Enachescu M, Borsig L, Bendas G, Simionescu M, VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes, Eur J Pharm Biopharm. 89 (2015) 18-29. doi: 10.1016/j.ejpb.2014.11.016

List of Book Chapters

  1. Fuior EV, Calin M (2020), Nanoparticle-based delivery of polyphenols for the treatment of inflammation-associated diseases. In Book: Advances and Avenues in development of novel carriers for Bioactives and biological agents, Editors: Manju Rawat Singh, Deependra Singh, Jagat Kanwar, Nagendra Singh Chauhan, 343-382, Academic Press, ELSEVIER, ISBN: 978-0-12-819666-3. Total Number of Matches displayed (Single Matches excluded): 90

  2. Calin M, Butoi E, Manea SA, Simionescu M, Manea A (2016). Lessons from experimental-induced atherosclerosis – valuable for the precision medicine of tomorrow. In book: Arterial Revascularization of the Head and Neck: Text Atlas for Prevention and Management of Stroke, pp.341-365, Editor Horia Muresian, SPRINGER, New York, DOI: 10.1007/978-3-319-34193-4_17, ISBN-10: 331934191X, ISBN-13: 978-3319341910 (Total Number 10 according Karlsruhe Virtual Catalogue). Total Number of Matches displayed (Single Matches excluded): 71

  3. Calin, M. (2012) Immunoliposomes for Specific Drug Delivery, in Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications (editors Y. Pathak and S. Benita), 229-266, JOHN WILEY & SONS, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118229019.ch12 (Total Number 53/2020 according Karlsruhe Virtual Catalogue).

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