Proiecte

PROIECTE ÎN LUCRU

• 2023-2026 Programul de Finantare PNRR, codul proiectului: PNRR-III-C9-2022–I8-CF93

Titlul Proiectului: Noi strategii nanoterapeutice care țintesc mecanismele implicate în tranziția fibroblast-miofibroblast pentru tratamentul fibrozei cardiace

Acronim: HeartCure

Director de Proiect: Prof. Dr. Rostyslav Bilyy

Cercetatori Principali: Dr. Habil CSI Manuela Calin, Dr. Habil CSI Adriana Georgescu, Dr. Habil CSI Elena Butoi

Scopul proiectului: Explorarea capacitãţii exozomilor derivaţi de la neutrofilele supuse netozei de a modula tranziţia fibroblastului cardiac la miofibroblast în fibroza cardiacã; investigarea mecanismelor responsabile şi a markerilor specifici pentru identificarea miofibroblaştilor cardiaci

Obiectivul 1: Descifrarea in vitro a rolului exozomilor derivați din neutrofile care suferă NEToză în tranziția fibroblastelor cardiace la miofibroblaste și explorarea mecanismelor potențiale implicate

Obiectivul 2: Demonstrarea in vivo a contribuției exozomilor derivați din neutrofile care suferă NEToză la tranziția fibroblastelor către miofibroblaste prin transferul de microARN

PROIECTE FINALIZATE

PROIECTE INTERNATIONALE

• 2016-2020 Competitiveness Operational Programme Grant, code SMIS: 104362, Contract no. 115/13.09.2016, “Targeted therapies for diabetes - related aortic valve disease’’. Acronym: THERAVALDIS, 8657500 lei. Specialist in implementation Project Team: PhD Adriana Georgescu; Executive Manager: Acad. Ileana Mânduțeanu; Project Manager: PhD Agneta Simionescu; Project leader: PhD Agneta Simionescu, Clemson University, USA

• 2012-2014 Capacity project: ERC-like – type "Grant Support", ID PNII-CT-ERC-2012–1. “Circulating platelet microparticles and endothelial progenitor cells in vascular atherosclerosis: new pathophysiological and therapeutic implications”.Grant nr.6/18.07.2012; 1 500 000 RON. Project manager: PhD Adriana Georgescu

• 2008-2011 COST Programme EU COST Action BM 0602. “Adipose tissue cells dialogue in obesity, diabetes and inflammation; search for molecules of pharmacological potential in reducing adipose tissue inflammatory proteins”. Project manager: Acad. Doina Popov, Institute of Cellular Biology and Pathology –‘N. Simionescu’

• 2005-2008 Specific Support Action, PC6, SERA Project, No. 016873. "Strengthening the European Research Area by Reinforcement of Romanian Research Competency in Genomics and Proteomics of Major Global Risk Diseases: Atherosclerosis, Diabetes and its Complications". Project manager: Acad. Maya Simionescu, Institute of Cellular Biology and Pathology –‘N. Simionescu’

• 2001-2002 Grant from the Deutsche forschungsgemeinschaft (Dfg). Grant in collaboration with Institute of Pharmacy and Food Chemistry, Friedrich-AlexanderUniversity Erlangen-Nuremberg, Erlangen, Germany, “Detection of non-enzymatic glycation products of cellular ADN using experimental models of diabetic animals”. Project manager: PhD Adriana Georgescu

PROIECTE NATIONALE

• 2019-2023 NO Grants, code RO-NO-2019-0544, Project contract no. 21/2020. “Supportive therapy for diabetes by increasing the stress endurance and regenerative capacity of β-cells. Acronym: BETAUPREG, 1.185.000 Euro. Project manager: PhD Ana-Maria Vãcaru, Institute of Cellular Biology and Pathology ‘N. Simionescu’

•2020-2022 Young Teams Research Grant, code PN-III-P1-1.1-TE-2019-0811,Grant no 97 /04.09.2020, “Immune modulation of T-cells by platelets and platelet-derived microvesicles in experimental induced atherosclerosis; the role of microRNA-142-3p”, Acronym: IMPLEXIA,431 900 lei. Project manager: PhD Nicoleta Alexandru

• 2018-2021 PCCDI Grant, code PN-III-P1-1.2-PCCDI-2017-0527/Contract no. 83 PCCDI/2018, “Development of BIOnanotechnologies based on extracellular vesicles for early diagnosis, prognosis and therapy of atherosclerotic disease”. Acronym: BIOVEA, 5.625,000 lei. Partners: National Institute for Research and Development in the field of Pathology and Biomedical Sciences "Victor Babeş" Bucharest (INCDVB); University of Medicine and Pharmacy "Carol Davila" Bucharest (UMFCD); Emergency Clinical Hospital "Pius Brînzeu" Timişoara - Research Center OncoGen (OncoGen). Project manager: PhD Adriana Georgescu

• 2018-2021 PCCDI Grant, code PN-III-P1-1.2-PCCDI-2017-0797/ Contract no. 66 PCCDI/2018, “Pathogenic mechanisms and personalized treatment in pancreatic cancer using multi-omics technologies”. Acronym: PANCNGS. Partners: University of Bucharest, Faculty of Biology: Department of Anatomy, Physiology and Biophysics; University of Medicine and Pharmacy, Craiova; IBPC-‘N. Simionescu’. Project manager: M.D., I. Popescu, Fundeni Clinical Institute, Bucharest, Project responsible IBPC: Acad. Maya Simionescu

• 2018-2020 PCCDI Grant, code PN-III-P1-1.2-PCCDI-2017-0749/Contract no. 45 PCCDI/2018, “Bioactive nanostructures for innovative therapeutic strategies”. Acronym: NANO-LIFE. Project manager: Prof. Dr Laurentiu Mogoanta, University of Medicine and Pharmacy, Craiova, Partners: Politehnica University of Bucharest; Carol Davila University of Medicine and Pharmacy; Institute of Cellular Biology and Pathology –“N. Simionescu”

•2015-2017 Young Teams Research Grant, codePN-II-RU-TE-2014-4-0525, Grant no 79/01.10.2015, “Microparticles as intracellular delivery strategies for microRNAs and potential therapies for atherosclerotic vascular disease”, Acronym: MISTAD, 550 000 lei. Project manager: PhD Adriana Georgescu

• 2015-2017 Young Teams Research Grant, codePN-II-RU-TE-2014-4-0523,Grant no 80/01.10.2015, “New insights in platelet-endothelial progenitor cell interplay in atherosclerotic disease”, Acronym: NICAD, 550 000 lei. Project manager: PhD Nicoleta Alexandru

• 2014-2016 PCCA Grant, code PN-II-PT-PCCA-2013-4-2154, Contract no. 207/2014, “Developing a protocol for selecting patients with obesity and type 2 diabetes mellitus (T2DM) eligible for diabetes remission after metabolic surgery”, Acronym: CREDOR. Project manager: M.D., Cãtãlin Copãiescu, Regina Maria Hospital, Ponderas Hospital, Bucharest, Project responsible IBPC: PhD Gabriela Costache

• 2014-2016 PCCA Grant, code PN-II-PT-PCCA-2013-4-2267,”Biodegradable implants from magnesium alloys used in foot and knee surgery”. Project manager: PhD Iulian Antoniac, Politehnica University of Bucharest

• 2014-2016 PCCA Grant, code PN-II-PT-PCCA-2013-4-1958, ”Multifunctional coatings for load bearing implants made of novel titanium-based alloy”. Project manager: PhD Alina Vladescu, National Institute for Research and Development in Optoelectronics, Bucharest

• 2011-2014 Young Teams Research Grant, codePNII-TE 26/2011-2014, “Investigation of molecular mechanisms of endothelin system in diabetes; development of new pharmacological strategies to improve vascular function”. Project manager: PhD Simona-Adriana Manea, Institute of Cellular Biology and Pathology –‘N. Simionescu’

• 2008-2011 PARTNERSHIP PNCDI-2 Grant, Grant no. 42138/ 1.10.2008, “Ratio of circulating microparticles to endothelial progenitor cells, a new cellular marker of endothelial dysfunction induced by combined hypertension and hypercholesterolemia; anti-atherosclerotic effect of irbersartan”. Partners: Cardiology Clinic of University Emergency Hospital Floreasca. Project manager: PhD Adriana Georgescu

• 2008-2011 IDEI PNCDI-2 Grant, Grant no. 1159/19.01.2009, “Vascular complications of small arteries in patients with obesity associated or not with type 2 diabetes; the endothelial dysfunction and insulin resistance”. Project manager: PhD Adriana Georgescu

• 2008-2009 TD type PNCDI-2 Grant, code PN-II-RU-TD-2008-3,TD-50, Grant no 11/2.06.2008, “The studies of platelet dysfunction associated with vascular system changes in ageing and pathological conditions”, 42 500 lei. Project manager: PhD Nicoleta Alexandru

• 2007-2008 TD type PNCDI-2 Grant, code: TD-448, Grant no. 69GR/11.05.2007, Topic 6. “Strategies to combat cardiovascular complications in obesity: the anti-inflammatory effect of Rosiglitazone in the recovery of atheroma instability and endothelial dysfunction caused by adipokines”. Project manager: PhD Alina Constantin

• 2006-2008 Excellence Research Projects for young researchers (CEEX) Grant, Grant no. 15121/2006-2008,”The effect of elevated levels of shed membrane microparticles on the function of the peripheral veins at patients with chronic venous insufficiency”. Project manager: PhD Adriana Georgescu

•2005-2006 Grant from Romanian Academy, “Cellular senescence in the kidneys- a genetically determined process or a consequence of oxidative stress and nitrosative stress?”. Project manager: PhD. Mãdãlina Dumitrescu, Institute of Cellular Biology and Pathology –‘N. Simionescu’

• 2005-2008 Excellence Research Projects, “The alteration of the cellular and molecular mechanisms and of gene expression in the cardiovascular disease and diabetes/ obesity, the major alteration of the metabolic syndrome – the fundamental and clinical researches”. Acronym: AMCADO. Project manager: Acad. Maya Simionescu, Institute of Cellular Biology and Pathology ‘N. Simionescu’

•2004-2006 VIASAN PNCDI Grant, grant no. 422/ 6.10.2004,“Adiponectin as mediator of the insulin activated intracellular signaling - clinical implications in obesity associated with type 2 diabetes”. Project manager: PhD Alina Constantin

•2004-2006 VIASAN PNCDI Grant, grant no. 347/ 1.10.2004, “The effect of the enoxaparin (a low molecular weight heparin) in the reestablishment of the endothelial vascular dysfunctions in aging and in diabetes; the involvement of the mitogen-activated protein kinase evidentiated by changes in the expression of c-fos gene and transcription factor AP-1”. Project manager: PhD Adriana Georgescu

• 2003-2005 VIASAN PNCDI Grant, “Theimpact of obesity on diabetes and cardiovascular diseases generation in urban communities in Romania- a population, pathophysiological and genetic study”. Acronym: OBEDIAGEN, 60,000 Euro. Partners: National Institute for Diabetes, Nutrition and Metabolic Diseases „N. Paulescu” and Anthropology Institute „Fr. Rainer”, Project manager: Acad. Anca Sima, Institute of Cellular Biology and Pathology –‘N. Simionescu’

• 2003-2005 CERES PNCDI Grant, “The studies on the cerebral vasculature in aging”. Project manager: PhD Elena Constantinescu, Institute of Cellular Biology and Pathology –‘N. Simionescu’

• 2003-2004 VIASAN PNCDI Grant, “Possibilities for reestablishment of vascular dysfunction and biochemical changes in diabetes and atherosclerosis”. Project manager: PhD Adriana Georgescu

• 2002-2005 VIASAN PNCDI Grant, grant no. 171/ 7.10.2002, “The pharmacological properties and the cellular mechanisms involved in the effect of nebivolol in the renal artery in diabetes; the experimental data”. Project manager: PhD Adriana Georgescu

● 2002 National Consortium: Institute of Diabetes, Nutrition and Metabolic Diseases “Prof. Dr N. Paulescu”, “Cantacuzino” Institute and Institute of Cellular Biology and Pathology “N. Simionescu”, “Effect of antioxidants on carbonyl stress modulation in diabetes”. Project manager: PhD Alina Constantin

● 2001-2003 VIASAN PNCDI Grant, “The cardiovascular changes associated with type 1 diabetes at transgenic mouse model”. Project manager: PhD Doina Popov

● 2001-2002 VIASAN PNCDI Grant, grant no. 110/ 29.10.2001, “The effect of of enoxaparin sodium on the vascular reactivity of the resistance arteries in aging and in diabetes; the role of nitric oxide”. Project manager: PhD Adriana Georgescu

● 2001-2002 Grant Awarded By Romanian Research and technology Ministry, grant no. 7051/2001.”The gap junctions and the vascular reactivity of the mesenteric resistance arteries; the effect of the heptanol”. Project manager: PhD Adriana Georgescu

● 2001 MEC. “Endothelial nitric oxide synthase gene polymorphisms as potential risk factors for developing cardiovascular complications in diabetes”. Project manager: PhD Gabriela Costache

● 2000-2001. ANSTI. “A new action for clotrimazole: modulation of the vascular reactivity of the resistance arteries and of the metabolism of cells within the vascular wall”. Project manager: PhD Gabriela Costache

● 2000 Grant from Romanian Academy, Grant no. 138/ 1.10.2000. “The study of the mechanisms involved in the vascular response of the resistance arteries in the presence of bradykinine. The effect of hyperglycemiahyperlipemia on the endothelium dependent relaxation”. Project manager: PhD Adriana Georgescu

● 2000 Grant Awarded By Romanian Research and technology Ministry, Grant no. 55/ 1.12.2000. “The effect of the combined hyperglycemia –hyperlipemia on the vascular reactivity of the resistance arteries in the presence of potassium vasoconstrictor. The involved cellular mechanism”. Project manager: PhD Adriana Georgescu

• 1999-2000 Grant from Romanian Academy, Grant no. 31/ 1999. “The role of aging and of association for a long time of the hyperglycemia-hyperlipemia in the formation of the glycated irreversible proteins. The effect of the in vivo administration by Larginine”. Project manager: PhD Adriana Georgescu

● 1999 Grant Awarded By Romanian Research and technology Ministry. “The effect of simultaneously hyper-glycemiahyperlipemia on the morphological and functional changes of the organs affected in hypertension”. Project manager: PhD Doina Popov

● 1999 Grant Awarded By Romanian Research and technology Ministry, Grant no. 881/ 10.09.1999. “The effect of the simultaneously hyperglycemia –hyperlipemia on the vascular reactivity of the resistance arteries in the presence of PGF2alpha vasoconstrictor. The involved cellular mechanism”. Project manager: PhD Adriana Georgescu

PREMII

● Prize of the Award Committee of the 44^th Anniversary Symposium Of The Institute Of Cellular Biology And Pathology “Nicolae Simionescu” held jointly with 40th Annual Scientific Session Of The Romanian Society For Cell Biology, for poster presentation, Bucharest, Romania, 2023 (Ioana Karla Comarița et al.)
● Prize for Poster Presentation to “22nd World Congress of International Federation for the Surgery of Obesity and Metabolic Disorders”, London, UK, 2017 (Alina Constantin et al.)
● Prize of the Award Committee of the 3rd International Congress and 29th Annual scientific session of Romanian Society for Cell Biology, Arad (RO)-Szeged (HU), 2011 (Adriana Georgescu et al.)
● “Dr. Constantin Velican” Award of the Romanian Society for Cell Biology, 2010 (Adriana Georgescu); 2001 (Doina Popov)
● Developing World Scientist Grants of the International Society on Thrombosis and Haemostasis for the presentation at XXII Congress of International Society on Thrombosis and Haemostasis, Boston – USA, 2009 (Adriana Georgescu)
● Prize offered by Romanian Academy, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, for successful scientific activities and published papers in the sixth frame work program of the European Community. Specific Support Action, INCO project. 2005-2008, SERA project, at the International Symposium Translational Research in Vascular Medicine, Bucharest, Romania, 2008 (Adriana Georgescu); 2008 (Nicoleta Alexandru)
● “Nicolae Simionescu” of the Romanian Academy, 2024 (Nicoleta Alexandru-Moise, Alina Constantin, Andreea-Miruna Nemecz); 2008 (Adriana Georgescu); 2004 (Doina Popov)
● Award offered by Romanian Academy, Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’, for successful scientific activities in the sixth frame work program of the European Community. Specific Support Action, INCO project. 2005-2008, SERA project, Bucharest, Romania, 2007 (Adriana Georgescu)
● “European society on Vascular Biology and Medicine” Award for paper presentation, 4th European Meeting on Vascular Biology and Medicine, Bristol, U.K., 2007 (Adriana Georgescu)
● Second Prize at the European life scientist Organization Meeting, Nice, France, 2002 (Adriana Georgescu)
● “Young Investigator” Award of the Healthy Nutrition Foundation, 2002 (First Prize-Adriana Georgescu, Second Prize-Alina Constantin (Carale))
● “Agora Diabetologica” Award of the Romanian Society for Diabetes, Nutrition and Metabolic Diseases, Berlin-Chemie, Menarini Group and Eli Lilly, 2002 (Alina Constantin (Carale))
● “Emil Racoviță “Award of the Romanian Academy, 1991 (Doina Popov)
● Original Article Awards of the Ministry for Education and Research (45 awarded articles)