Projects

Research

Ongoing projects

• International:

(1) Project title: Development of a novel immunomodulatory therapy against cardiac inflammation in myocardial infarction, myocarditis and sepsis (IMMUNOCARD). Project director: Alexandru Schiopu. Funding: European Commission. Romania’s National Recovery and Resilience Plan, PNRR-III-C9-2022-I8, CF148/15.11.2022, Financing Contract no. 760061/23.05.2023. Period: 2023-2026.

• National:

1)Project title: “Advanced therapeutic strategy in atherosclerosis based on epitranscriptomic reprogramming.” Project director: Adrian Manea. Funding agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2025-2028.

(2) Project title: Center of Excellence for Advanced Translational Research in Cardiovascular and Cerebrovascular Diseases (SEARCH-VASC). Project director: Dragos Vinereanu. Key person: Adrian Manea. Funding agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2026-2030.

Completed projects

• International:

(1) Project title: “Investigation of the role of PPARs in mediating oxidative stress signals in vascular cells in diabetes“.Project director: Adrian Manea.Partner: Prof. Shlomo Sasson, The Hebrew University of Jerusalem, Israel.Funding agency: European Foundation for the Study of Diabetes - New Horizons Collaborative Research Initiative. Period: 2010-2011.

(2) Project title: Targeted therapies for aortic valve disease in diabetes”. Project director: Agneta Simionescu. Funding: European Commission. Period: 2016-2021.

• National:

(1) Project title: “Advanced therapeutic strategy in atherosclerosis based on epigenetic reprogramming”. Project director: Adrian Manea. Funding agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2021-2023.

(2) Project title: “Advanced therapeutic strategy in diabetic nephropathy based on the targeting of epigenetic mechanisms underlying renal failure and metabolic memory”. Project director: Simona-Adriana Manea. Funding agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2022-2024.

(3) Project title: “Advanced theranostic strategy in atherosclerosis integrating pharmaco-epigenomic interventions and biomimetic microbubbles as ultrasound-mediated targeted drug delivery systems”. Project director: Adrian Manea. Funding agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2020-2022.

(4) Project title: “Innovative triterpenes-based pharmacological strategy for the treatment of diabetes-associated micro- and macrovascular disorders – preclinical study”. Project director: Simona-Adriana Manea. Funding agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2020-2022.

(5) Project title: Targeting innate immune mechanisms to improve risk stratification and to identify future therapeutic options in myocardial infarction. Project director: Maya Simionescu, Coordinator, Institute of Cellular Biology and Pathology "Nicolae Simionescu". Partners: University of Medicine, Pharmacy, Science and Technology, Targu Mures. University of Medicine and Pharmacy "Carol Davila" Bucharest. Agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2018 – 2022.

(6) Project title: “Preclinical strategy to reduce vascular inflammation and oxidative stress by targeting novel non-coding RNA pathways in atherosclerosis”. Project director: Adrian Manea. Funding agency:Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI).Period: 2018-2020.

(7) Project title: Novel epigenetic pathways to induce anti-inflammatory macrophages as potential therapeutic targets in atherosclerosis. Project director: Maya Simionescu. Agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI).Period: 2017-2019.

(8) Project title: “Nanotechnology-based method for non-invasive molecular imaging of oxidative stress in cardiovascular disorders”. Project director: Adrian Manea. Funding agency: UEFISCDI. Period: 2017-2018.

(9) Project title: “Investigation of molecular mechanisms of endothelin system in diabetes; development of new pharmacological strategies to improve vascular function”. Project director: Simona-Adriana Manea. Funding agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2011-2014.

(10) Project title: Molecular regulation of oxidative stress in atherosclerosis: development of an innovative nanocarrier-based antioxidant therapy. Project director: Maya Simionescu. Agency: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI). Period: 2011-2016.

(11) Project title: “Novel molecular pharmacology strategies for reduction of oxidative stress and inflammation in the vascular wall cells in diabetes”. Project director: Adrian Manea. Funding agency: UEFISCDI. Period: 2010-2013.

(12) Project title: “Inflammation and oxidative stress in atherosclerosis: cellular and molecular mechanisms, identification and characterization of novel biomarkers of vascular dysfunction”. Project director: Adrian Manea. Funding agency: UEFISCDI. Period: 2009-2011.