Publications

• Publications / Articles

• Vlad ML, Mares RG, Jakobsson G, Manea SA, Lazar AG, Preda MB, Popa MA, Simionescu M, Schiopu A, Manea A.Therapeutic S100A8/A9 inhibition reduces NADPH oxidase expression, reactive oxygen species production and NLRP3 inflammasome priming in the ischemic myocardium. Eur J Pharmacol. 2025 Jun 5;996:177575. doi: 10.1016/j.ejphar.2025.177575.
• Manea SA, Vlad ML, Lazar AG, Muresian H, Simionescu M, Manea A.SET7 lysine methyltransferase mediates the up-regulation of NADPH oxidase expression, oxidative stress, and NLRP3 inflammasome priming in atherosclerosis. J Transl Med. 2025 Mar 17;23(1):339. doi: 10.1186/s12967-025-06338-0.
• Jakobsson G, Papareddy P, Andersson H, Mulholland M, Bhongir R, Ljungcrantz I, Engelbertsen D, Björkbacka H, Nilsson J, Manea A, Herwald H, Ruiz-Meana M, Rodríguez-Sinovas A, Chew M, Schiopu A. Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction. Critical Care. 2023; 27(1):374. doi: 10.1186/s13054-023-04652-x.
• Simona-Adriana Manea, Mihaela-Loredana Vlad, Alexandra-Gela Lazar, Horia Muresian, Maya Simionescu, Adrian Manea. Pharmacological inhibition of lysine-specific demethylase 1A reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice by a mechanism involving decreased oxidative stress and inflammation; potential implications in human atherosclerosis. Antioxidants (Basel), 2022; 11(12):2382. doi: 10.3390/antiox11122382.
• Alexandra-Gela Lazar, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, Simona-Adriana Manea. Activated histone acetyltransferase p300/CBP-related signalling pathways mediate up-regulation of NADPH oxidase, inflammation, and fibrosis in diabetic kidney. Antioxidants (Basel). 2021; 10(9):1356. doi: 10.3390/antiox10091356.
• Simona-Adriana Manea, Mihaela-Loredana Vlad, Daniela Rebleanu, Alexandra-Gela Lazar, Ioana Madalina Fenyo, Manuela Calin, Maya Simionescu, Adrian Manea. Detection of vascular reactive oxygen species in experimental atherosclerosis by high-resolution near-infrared fluorescence imaging using VCAM-1-targeted liposomes entrapping a fluorogenic redox-sensitive probe. Oxidative Medicine and Cellular Longevity. 2021; 2021:6685612. doi: 10.1155/2021/6685612.
• Simona-Adriana Manea, Mihaela-Loredana Vlad, Ioana Madalina Fenyo, Alexandra-Gela Lazar, Monica Raicu, Horia Muresian, Maya Simionescu, Adrian Manea. Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis, Redox Biology, 28: 101338, 1-13, 2020.
• Mihaela-Loredana Vlad, Simona-Adriana Manea, Alexandra-Gela Lazar, Monica Raicu Horia Muresian, Maya Simionescu, Adrian Manea. Histone Acetyltransferase-dependent pathways mediate upregulation of NADPH oxidase 5 in human macrophages under inflammatory conditions: a potential mechanism of reactive oxygen species overproduction in atherosclerosis. Oxid Med Cell Longev. 2019 Sep 2;2019: 3201062. doi: 10.1155/2019/3201062. eCollection 2019.
• Simona-Adriana Manea, Mihaela-Loredana Antonescu, Ioana Madalina Fenyo, Monica Raicu, Maya Simionescu, Adrian Manea. Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes. Redox Biology. 2018, 16: 332-343. doi: 10.1016/j.redox.2018.03.011.
• Manea SA, Fenyo IM, Manea A. c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression. Int J Biochem Cell Biol. 2016 Jun;75:123-30. doi: 10.1016/j.biocel.2016.04.008.
• Aguado A, Fischer T, Rodríguez C, Manea A, Martínez-González J, Touyz RM, Hernanz R, Alonso MJ, Dixon DA, Briones AM, Salaices M. Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. J Hypertens. 2016 Feb;34(2):253-65. doi: 10.1097/HJH.0000000000000801.
• Manea SA, Constantin A, Manda G, Sasson S, Manea A. Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms. Redox Biol. 2015 Aug; 5:358-66. doi: 10.1016/j.redox.2015.06.012.
• Manda G, Isvoranu G, Comanescu MV, Manea A, Debelec Butuner B, Korkmaz KS. The redox biology network in cancer pathophysiology and therapeutics. Redox Biol. 2015 Aug; 5:347-57. doi: 10.1016/j.redox.2015.06.014.
• Manea A, Manea SA, Gan AM, Constantin A, Fenyo IM, Raicu M, Muresian H, Simionescu M. Human monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in atherosclerosis. Biochem Biophys Res Commun. 2015 May 22;461(1):172-9. doi: 10.1016/j.bbrc.2015.04.021.
• Manea A, Manea SA, Todirita A, Albulescu IC, Raicu M, Sasson S, Simionescu M. High-glucose-increased expression and activation of NADPH oxidase in human vascular smooth muscle cells is mediated by 4-hydroxynonenal-activated PPARα and PPARβ/δ. Cell Tissue Res. 2015 Aug;361(2):593-604. doi: 10.1007/s00441-015-2120-0.
• Gan AM, Butoi E, Manea A, Pirvulescu MM, Stan D, Simion V, Calin M, Simionescu M, Manduteanu I. Functional analysis of the fractalkine gene promoter in human aortic smooth muscle cells exposed to proinflammatory conditions. FEBS J. 2014 Sep;281(17):3869-81. doi: 10.1111/febs.12921.
• Manea SA, Todirita A, Raicu M, Manea A. C/EBP transcription factors regulate NADPH oxidase in human aortic smooth muscle cells. J Cell Mol Med. 2014 Jul;18(7):1467-77. doi: 10.1111/jcmm.12289.
• Manea SA, Todirita A, Manea A. High glucose-induced increased expression of endothelin-1 in human endothelial cells is mediated by activated CCAAT/enhancer-binding proteins. PLoS One. 2013 Dec 23;8(12): e84170. doi: 10.1371/journal.pone.0084170. eCollection 2013.
• Manea A, Fortuno A, Martin-Ventura JL. Oxidative stress in cardiovascular pathologies: genetics, cellular, and molecular mechanisms and future antioxidant therapies. Oxid Med Cell Longev. 2012; 2012:373450. doi: 10.1155/2012/373450.
• Gan AM, Butoi ED, Manea A, Simion V, Stan D, Parvulescu MM, Calin M, Manduteanu I, Simionescu M. Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1 expression by TLR4 and Gi-protein pathways. Cell Tissue Res. 2013 Jan;351(1):161-74. doi: 10.1007/s00441-012-1510-9.
• Manea A, Manea SA, Florea IC, Luca CM, Raicu M. Positive regulation of NADPH oxidase 5 by proinflammatory-related mechanisms in human aortic smooth muscle cells. Free Radic Biol Med. 2012 May 1;52(9):1497-507.
• Manea A, Simionescu M. Nox enzymes and oxidative stress in atherosclerosis. Front Biosci (Schol Ed). 2012 Jan 1; 4:651-70.
• Fenyo IM, Florea IC, Raicu M, Manea A. Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice. Vascul Pharmacol. 2011 Mar-Jun;54(3-6):100-6.
• Manea SA, Robciuc A, Guja C, Heltianu C.Identification of gene variants in NOS3, ET-1 and RAS that confer risk and protection against microangiopathy in type 2 diabetic obese subjects. Biochemical and Biophysical Research Communications,407: 486-490,2011.
• Manea A. NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology. Cell Tissue Res. 2010 Dec;342(3):325-39.
• Manea A, Tanase LI, Raicu M, Simionescu M. Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-kappaB in human aortic smooth muscle cells. Biochem Biophys Res Commun. 2010 Jun 11;396(4):901-7.
• Manea SA, Manea A, Heltianu C. Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells. Cell Tissue Res. 2010 Apr;340(1):71-9.
• Manduteanu I, Pirvulescu M, Gan AM, Stan D, Simion V, Dragomir E, Calin M, Manea A, Simionescu M. Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1443-8.
• Manea A, Tanase LI, Raicu M, Simionescu M. Jak/STAT signaling pathway regulates Nox1 and Nox4-based NADPH oxidase in human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):105-12.
• Sima AV, Botez GM, Stancu CS, Manea A, Raicu M, Simionescu M. Effect of irreversibly glycated LDL in human vascular smooth muscle cells: lipid loading, oxidative and inflammatory stress. J Cell Mol Med. 2010 Dec;14(12):2790-802.
• Heltianu C,Manea SA, Guja C, Robciuc A, Ionescu-Targoviste C. Polymorphism in exon 7 of the endothelial nitric oxide synthase gene is associated with low incidence of microvascular damage in type 1 diabetic neuropathy. Central European Journal of Biology, 4(4): 521–527, 2009.
• Manea A, Manea SA, Gafencu AV, Raicu M, Simionescu M. AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit. Arterioscler Thromb Vasc Biol. 2008 May;28(5):878-85.
• Heltianu C, Manea SA, Guja C, Mihai C, Ionescu-Tirgoviste C. Correlation of low molecular weight advanced glycation end products and nitric oxide metabolites with chronic complications in type 1 diabetic patients. Central European Journal of Biology, 3(3): 243-249, 2008.
• Manea A, Manea SA, Gafencu AV, Raicu M. Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells. Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):163-72.
• Safciuc F, Constantin A, Manea A, Nicolae M, Popov D, Raicu M, Alexandru D, Constantinescu E. Advanced glycation end products, oxidative stress and metalloproteinases are altered in the cerebral microvasculature during aging. Curr Neurovasc Res. 2007 Nov;4(4):228-34.
• Sfrent-Cornateanu R, Mihai C, Balan SA, Ionescu R, Moldoveanu E. The IL - 6 promoter polymorphism is associated with disease activity and disability in systemic sclerosis. Journal of Cellular and Molecular Medicine, 10(4): 955-959, 2006.
• Manea A, Raicu M, Simionescu M. Expression of functionally phagocyte-type NAD(P)H oxidase in pericytes: effect of angiotensin II and high glucose. Biol Cell. 2005 Sep;97(9):723-34.
• Dragomir E, Manduteanu I, Voinea M, Costache G, Manea A, Simionescu M. Aspirin rectifies calcium homeostasis, decreases reactive oxygen species, and increases NO production in high glucose-exposed human endothelial cells. J Diabetes Complications. 2004 Sep-Oct;18(5):289-99.
• Manea A, Constantinescu E, Popov D, Raicu M. Changes in oxidative balance in rat pericytes exposed to diabetic conditions. J Cell Mol Med. 2004 Jan-Mar;8(1):117-26.
• Voinea M, Georgescu A, Manea A, Dragomir E, Manduteanu I, Popov D, Simionescu M. Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes. Eur J Pharmacol. 2004 Jan 19;484(1):111-8.