Projects

Ongoing projects

• 2023–2026 STROMA – Strengthening Romanian competence in metabolic syndrome research by exploring the role of apolipoprotein A2 in dyslipidemia, obesity, and type II diabetes mellitus (PNRR contract 258/2023), led by Kyriakos Kypreos.
• 2023–2026 CardioScope – Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy (HORIZON-MSCA-2021-SE-01-01 CARDIOSCOPE Grant Agreement nº 101086397). Project director: Dr. Paolo Magni (University of Milan). Coordinator of the Romanian team: Anca Gafencu.

Completed projects

• 2022-2024: “A novel anti-atherosclerotic chimeric protein that impedes the infiltration of the inflammatory cells in the vessel wall”PN-III-P4-PCE-2021-1755, Project Director A. Gafencu.

• 2020-2022: Demonstration of the enhanced anti-atherosclerotic potential of apolipoprotein E targeted to the activated endothelium, by fusion with VCAM-1 binding peptide -project PN-III-P2-2.1-PED-2019- 4574 Project Director A. Gafencu
• 2019-2022: Integrative Personal Omics Profiles in Glioblastoma Recurrence and Therapy Resistance – ERA-NET PerMed – A. Gafencu - Coordinator for Romanian team
• 2016-2020 Improve institutional competitiveness in the field of type 1 diabetes by developing an innovative concept of immunotherapy based on mesenchymal stromal cells ACRONYM: DIABETER Project Director Nadir Askenasy.
• 2015-2017: Genetically engineered apolipoproteins immobilized on nanoparticles: a Molecular Trojan horse targeting atherosclerotic plaque (Acronym: APGEN) PN-II-RU-TE-2014-4-2143, Projects for Young Research Teams, supported by CNCSIS Romania (2015-2017), Project Director A. Gafencu.
• 2011-2016: Apolipoprotein E-based novel anti-atherosclerosis cell-therapy approaches, Exploratory research projects, project PN-II ID_PCE-2011-3-0591, supported by CNCSIS Romania (2011-2016), Project Director A. Gafencu.
• 2009-2011: Novel strategies employing genetic engineering to increase plasma HDL- the protective lipoproteins in atherosclerosis, Exploratory research projects:1307 supported by CNCSIS Romania, Project Director A. Gafencu.
• 2005-2007: Regulation of apolipoprotein gene clusters- an innovative therapeutic approach of neurodegenerative and cardiovascular diseases- Grant awarded by the Romanian Ministry of Research: “Excellence Research Program: Projects for Young Researchers.” Project Director A. Gafencu.
• 2005-2007: Regulation of the expression of the human apolipoprotein E gene in macrophages and the brain: new approaches for the treatment of dyslipidemias and Alzheimer’s Disease- Grant awarded by the Greek and Romanian Ministries of Research- to Prof Dimitris Kardassis and Dr. Anca Gafencu
• 2003-2005: ApoE gene regulation - therapeutic target in cardiovascular and neurodegenerative diseases -Grant awarded by the Romanian Ministry of Research- National Research Program for Biotechnology "BIOTECH" Project Director A. Gafencu.
• 2001-2003: Characterization of albumin and IgG receptors, expressed by the endothelial cells in normal and pathologic states Grant awarded by the Romanian Ministry of Research- National Research Program "CERES" Project Director A. Gafencu.
• 2000: Functional analysis of the IgG receptors in endothelial cells - Grant awarded by the Romanian Research Ministry Project Director A. Gafencu.
• 1999: Identification of FcR in human placental endothelial cells-Grant awarded by the Romanian Academy Project Director A. Gafencu.
• 1998: Immortalization of endothelial cells -Grant awarded by the Romanian Academy Project Director A. Gafencu.
• 1997-1998: Lipid composition of the microdomains of the endothelial cell membrane-Grant awarded by the Romanian Academy Project Director A. Gafencu.
• 1996-1999: Biochemical and functional characterization of the endothelial plasmalemma Grant awarded by the Romanian Research Ministry Project Director A. Gafencu.