Publications

2025

Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction, Boteanu RM, Suica VI, Uyy E, Ivan L, Mares RG, Simionescu M, Schiopu A, Antohe F, Journal of Advanced Research, 2025, IF: 11.4

2024

Short‑term S100A8/A9 Blockade Promotes Cardiac Neovascularization after Myocardial Infarction, J Cardiovasc Transl Res. RG Mares*, VI Suica*, E Uyy, RM Boteanu, L Ivan, IG Cocuz,A H Sabau,Vikas Yadav, I A Szabo, O Simion Cotoi, M E Tomut, G Jakobsson, M Simionescu, F Antohe*, A Schiopu*, (*equal contribution) 2024 Jul 15. Journal of Cardiovascular Translational Research, 2024, IF:2.4

Dihydrotestosterone Augments the Angiogenic and Migratory Potential of Human Endothelial Progenitor Cells by an Androgen Receptor-Dependent Mechanism Popa MA, Mihai CM, Șuică VI, Antohe F, Dubey RK, Leeners B, Simionescu M. 2024 Apr 29;25(9):4862. Int J Mol Sci. 2024, IF: 4.9

2023

Hepatic Alarmins and Mitochondrial Dysfunction under Residual Hyperlipidemic Stress Lead to Irreversible NAFLD, L Ivan, E Uyy, VI Suica, RM Boteanu, A Cerveanu-Hogas, R Hansen, F Antohe, Volume 11, Issue 2, Pages 284-294, Published 2023/4/28, Journal of Clinical and Translational Hepatology, 2023 IF: 5.065

Biotechnological advances and applications of human pluripotent stem cell-derived heart models Muniyandi P, O'Hern C, Popa MA, Aguirre A. Published 2023 Jul 25;11:1214431. Front Bioeng Biotechnol, 2023, IF: 4.3

2022

Exosome Proteomics Reveals the Deregulation of Coagulation, Complement and Lipid Metabolism Proteins in Gestational Diabetes Mellitus, EG Bernea*, VI Suica*, E Uyy*, A Cerveanu-Hogas, RM Boteanu, L Ivan, I Ceausu, DA Mihai, C Ionescu-Tîrgoviște, F Antohe, (*equal contribution) Volume 27, Issue 17, Pages 5502, Published 2022/8/26 Molecules, 2022 IF:4.6

Short-Term Blockade of Pro-Inflammatory Alarmin S100A9 Favorably Modulates Left Ventricle Proteome and Related Signaling Pathways Involved in Post-Myocardial Infarction Recovery, RM Boteanu, VI Suica, E Uyy, L Ivan, A Cerveanu-Hogas, RG Mares, M Simionescu, A Schiopu, F Antohe, Volume 23, Issue 9, Pages 5289, Published 2022/5/9 International Journal of Molecular Sciences 2022 IF:5.6

New born macrosomia in gestational diabetes mellitus, EG Bernea*, E Uyy*, DA Mihai, I Ceausu, C Ionescu‑Tirgoviste, VI Suica, L Ivan, F Antohe, (*equal contribution) Volume 24, Issue 6, Pages 1-12, Publication date 2022/12/1 Experimental and Therapeutic Medicine 2022 IF:2.7

Regulated cell death joins in atherosclerotic plaque silent progression, E Uyy, VI Suica, RM Boteanu, A Cerveanu-Hogas, L Ivan, R Hansen, F Antohe; Volume 12, Issue 1, Pages 1-14, Published2022/2/18 Journal Scientific Reports, 2022 IF:4.6

Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy, VI Suica, E Uyy, L Ivan, RM Boteanu, A Cerveanu-Hogas, R Hansen, F Antohe, Volume 23, Issue 19, Pages 11174, Publication date 2022/9/22 International Journal of Molecular Sciences 2022 IF:5.6

Fibroblast growth factor receptor-2 modulates the MMP2 and MMP14/TIMP1 ratio in human cardiac myofibroblasts, Popa, M. A., C. M. Mihai, F. Antohe, and M. Simionescu. Febs Open Bio, vol. 12, pp. 43-43. 111 River St, Hoboken 07030-5774, Nj Usa: Wiley, 2022. IF: 2.6

Changes in Serum Insulin and Proinsulin Levels in Gestational Diabetes-A Brief Review, E G Bernea, I Ceausu, DE Georgescu, C Ionescu-Tirgoviste, F Antohe, DA Mihai 23, 113 Research&Science Today 2022

Serum Levels of Adiponectine and Leptin in Gestational Diabetes Mellitus-Review EG Bernea, I Ceausu, Dragos E Georgescu, C Ionescu-Tirgoviste, F Antohe, DA Mihai Journal Nr 1, Volume 23, Pages 131 Research&Science Today 2022

2021

Proteomic Analysis of Estrogen-Mediated Enhancement of Mesenchymal Stem Cell-Induced Angiogenesis In Vivo. Mihai MC, Popa MA, Șuică VI, Antohe F, Jackson EK, Leeners B, Simionescu M, Dubey RK. 10(9):2181. Published: Aug 24 2021 Cells. 2021 IF: 7.666

Inflammatory status of the pancreas in NOD mice that do not develop overt diabetes Catrina AM, Popa MA, Văcaru AM, Fenyo IM. Published 2021 Jan-Mar;62(1):109-115. Rom. J Morphol Embryol, 2021, IF: 0.833

2020

Proteomics Of Regenerated Tissue In Response To A Titanium Implant With A Bioactive Surface In A Rat Tibial Defect Model, RM Boteanu, VI Șuică, L Ivan, F Safciuc, E Uyy, E Drăgan, SM. Croitoru, V Grumezescu, M Chirițoiu, LE. Sima, C Vlăgioiu, G Socol, F Antohe, Volume: ‏ 10Issue: ‏ 1Article Number: 18493 Published: ‏oct 28 2020 Scientific Reports 2020 IF: 4.38

Diabetic Nephropathy Associates With Deregulation Of Enzymes Involved In Kidney Sulphur Metabolism, E Uyy, VI Șuică, RM Boteanu, F Safciuc, A Cerveanu-Hogaș, L Ivan, C Stavaru, M Simionescu, F Antohe, Volume: ‏ 24Issue: ‏ 20Pages: ‏ 12131-12140 Published: oct 2020 Journal of Cellular and Molecular Medicine 2020 IF: 5.31

Analytical techniques for multiplex analysis of protein biomarkers, Van Gool A, Corrales F, Čolović M, Krstić D, Oliver-Martos B, Martínez-Cáceres E, Jakasa I, Gajski G, Brun V, Kyriacou K, Burzynska-Pedziwiatr I, Wozniak LA, Nierkens S, Pascual García C, Katrlik J, Bojic-Trbojevic Z, Vacek J, Llorente A, Antohe F, Suica V, Suarez G, t'Kindt R, Martin P, Penque D, Martins IL, Bodoki E, Iacob BC, Aydindogan E, Timur S, Allinson J, Sutton C, Luider T, Wittfooth S, Sammar M, Volume: ‏ 17 Issue: ‏ 4 Pages: ‏ 257-273Published: ‏APR 2 2020 Expert Review of Proteomics 2020 IF: 3.940

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions, A. I. Vişan, G. Popescu-Pelin, O. Gherasim, A. Mihăilescu, M. Socol, I. Zgura, M. Chiriţoiu, L. E. Sima, F. Antohe, L. Ivan, D. M. Vrânceanu, C. M. Cotruţ, R. Cristescu, and G. Socol, Volume: ‏ 12Issue: ‏ 3Article Number: 717 Published: ‏mar2020 Polymers 2020 IF: 4.329

Management of gestational diabetes-a review of current literature. EG Bernea, F Antohe, A Mihai, I Ceaușu, C Guja, C Ionescu-Tîrgoviște, Issue 1, Publication date 2020/3/1 Research&Science Today 2020

Biogenesis of Exosomes-A Review of Current Literature, EG Bernea, A Mihai, C Guja, C Ionescu-Tirgoviste, F Antohe, A Pietrosel, Volume 20, Pages 39, Publication date 2020" Research&Science Today 2020

Maternal and Fetal Complications of Gestational Diabetes-Review, EG Bernea, A Mihai, A Pietrosel, I Ceausu, F Antohe, C Ionescu-Tirgoviste, Volume 20, Pages 55, Publication date 2020 Research&Science Today 2020

2019

Mechanism of 17 beta-estradiol stimulated integration of human mesenchymal stem cells in heart tissue, M. C. Mihai, M. A. Popa, V. I. Şuică, F. Antohe, E. K. Jackson, M. Simionescu, and R. K. Dubey, Volume: ‏ 133 Pages: ‏ 115-124 Published: ‏ AUG 2019 Journal of Molecular and Cellular Cardiology 2019 IF: 4.133

Driving Precision Medicine through Proteomics and Metabolomics-12th Central and Eastern European Proteomic Conference (CEEPC), Bucharest, Romania, S. J. Gadher, F. Antohe, and H. Kovarova, Volume: ‏ 16 Issue: ‏ 7 Pages: ‏ 549-552 Published: ‏Jul 3 2019 Expert Review of Proteomics 2019 IF: 3.614

Evaluation of the immunogenicity of reverse-vaccinology derived staphylococcus aureus proteins on experimental endocarditis model, M Oprea, B Cordoş, M Străut, A Costache, F Antohe, A Onu, Volume 78, Issue 1, Pages 5-16, Publication date 2019" Romanian Archives of Microbiology and Immunology 2019

In Vivo Pharmacological and Anti-inflammatory Evaluation of Xerophyte Plantago sempervirens Crantz Farcaș AD, Moț AC, Pârvu AE, Toma VA, Popa MA, Mihai MC, Sevastre B, Roman I, Vlase L, Pârvu M. 2019 Jun 2; 2019: 5049643. Oxid Med Cell Longev, 2019, IF: 5.076

2018

Dihydrotestosterone induces pro-angiogenic factors and assists homing of MSC into the cardiac tissue, M. A. Popa, M. C. Mihai, A. Constantin, V. I. Şuică, C. Ţucureanu, R. Costache, F. Antohe, R. K. Dubey, and M. Simionescu, Volume: ‏ 60 Issue: ‏ 1Pages: ‏ 1-15 Published: ‏Jan 2018 Journal of Molecular Endocrinology 2018, IF: 3.744

Oxidative stress and gestational diabetes mellitus. The effects of supplements on oxidative stress, EG Bernea, F Antohe, A Mihai, C Ionecsu-Tirgoviste, Proc Rom Acad Ser B, Volume 20, Issue 2, Pages 121-131, 2018 Proceedings Of The Romanian Academy 2018

2017

Proteomic analysis of plasma molecular markers as predictors of differentiated thyroid cancer, A. E. Baciu*, E. Uyy*, V. I. Şuică*, R. M. Boteanu, A. I. Popescu, C. Giulea, D. Manda, C. Badiu, and F. Antohe, (*equal contribution) Volume: ‏ 69 Issue: ‏ 1 Article Number: 601 Published: ‏ 2017Romanian Reports in Physics 2017 IF: 1.582

High Resolution Mass Spectrometry Analysis Of Ribosomal Proteins In Experimental Diabetes, Uyy, E; Suica, VI; Boteanu, RM; Ivan, L; Safciuc, F; Antohe, F, Volume: ‏ 69 Issue: ‏ 1 Article Number: 602 Published: ‏ 2017Romanian Reports in Physics 2017 IF: 1.582

Alarmins in chronic noncommunicable diseases: Atherosclerosis, diabetes and cancer, R. M. Boteanu*, V. I. Şuică*, E. Uyy, L. Ivan, S. O. Dima, I. Popescu, M. Simionescu, and F. Antohe, (*equal contribution) Volume: ‏ 153 Special Issue: ‏ SI Pages: ‏ 21-29 Published: feb 5 2017 Journal of Proteomics 2017 IF: 3.722

Laser deposition of poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) - lysozyme microspheres-based coatings with anti-microbial properties, V. Grumezescu, A. M. Holban, L. E. Sima, M. B. Chiriţoiu, G. N. Chiriţoiu, A. M. Grumezescu, L. Ivan, F. Safciuc, F. Antohe, C. Florica, C. R. Luculescu, M. C. Chifiriuc, and G. Socol Volume: ‏ 521Issue: ‏ 1-2Pages: ‏ 184-195Published: ‏APR 15 2017 International Journal of Pharmaceutics 2017 IF: 3.862

2016

Endoplasmic Reticulum Chaperones Are Potential Active Factors in Thyroid Tumorigenesis, E. Uyy*, V. I. Şuică*, R. M. Boteanu, D. Manda, A. E. Baciu, C. Badiu, and F. Antohe, (*equal contribution) Volume: ‏ 15Issue: ‏ 9Pages: ‏ 3377-3387 Published: sep 2016 Journal of Proteome Research 2016 IF: 4.268

Comparative proteomic analysis of membrane microdomains isolated from two hyperlipidemic animal models, V. I. Şuică, E. Uyy, R. M. Boteanu, L. Ivan, and F. Antohe, Volume: ‏ 1864Issue: ‏ 9Pages: ‏ 1061-1071 Published: ‏sep 2016 Biochimica et Biophysica Acta-Proteins and Proteomics 2016 IF: 2.773

Preliminary structural ultrasonic characterization of hydroxyapatite, C. L. Popa, S. Antohe, F. Safciuc, MEC. El Kettani, D. Leduc, F. Antohe, and MV. Predoi, Volume: ‏ 11Issue: ‏ 3Pages: ‏ 997-1006 Published: ‏ iul-sep 2016 Digest Journal of Nanomaterials and Biostructures 2016, IF: 0.836

Prevalence of virulence markers and pHS-2-like plasmids among Shigella sonnei and Shigella flexneri isolates originating from shigellosis cases in Romania, D. Cristea, M. Oprea, A. S. Ciontea, F. Antohe, and C. R. Usein, Volume: ‏ 24 Issue: ‏ 1Pages: ‏ 103-110Published: ‏mar 2016 Revista Romana de Medicina de Laborator 2016, IF: 0.325

S100A4 and ERBB2 as co-factors in pancreatic cancer, Nastase, A., Dima, Sa, Tica, V., Florea, R. Sorop, A. Ilie, V. Eftimie, M. Paslaru, L. Herlea, V. Bacalbasa, N. Ivan, L. Uyy, E. Suica, V.I. Antohe, F. Iancu, I.V. Plesa, A. Botezatu, A. Duda, D.G. Diaconu, C.C., Volume 21, Issue 4, December 2016, Pages 259-266 Journal of Translational Medicine and Research, 2016

Testosterone stimulates proliferation and preserves stemness of human adult mesenchymal stem cells and endothelial progenitor cells. Corotchi MC, Popa MA, Simionescu M. 2016;57(1):75-80. Rom J Morphol Embryol, 2016, IF:0.670

2015

Alteration of actin dependent signaling pathways associated with membrane microdomains in hyperlipidemia, V. I. Şuică, E. Uyy, R. M. Boteanu, L. Ivan, and F. Antohe, Volume: ‏ 13Article Number: 30 Published: ‏ dec 1 2015 Proteome Science 2015 IF: 1.746

High-mobility group box 1 enhances the inflammatory process in diabetic lung, R. M. Boteanu, E. Uyy, V. I. Şuică, and F. Antohe, Volume: ‏ 583 Pages: ‏ 55-64 Published: ‏oct 1 2015 Archives of Biochemistry and Biophysics 2015 IF: 2.807

Mass spectrometry-based proteomics, Antohe, F., Volume: ‏ 11Issue: ‏ 2 Pages: ‏ 139-142 Published: apr-iun 2015 Acta Endocrinologica-Bucharest 2015 IF: 0.235

Carbapenemase-Producing Klebsiella pneumoniae in Romania: A Six-Month Survey, B. E. Lixandru, A. I. Cotar, M. Străuţ, C. R. Usein, D. Cristea, S. Ciontea, D. Tatu-Chiţoiu, I. Codiţă, A. Rafila, M. Nica, M. Buzea, A. Baicus, M. C. Ghiţă, I. Nistor, C. Tuchilus, M. Indreas, F. Antohe, C. Glasner, H. Grundmann, A. Jasir, and M. Damian Volume: ‏ 10Issue: ‏ 11Article Number: e0143214 Published: ‏ nov 23 2015 Plos One 2015 IF: 3.057

An in vitro method for adhesion of fresh adult murine heart slices on Collagen - Coated surfaces, Popa MA & Corotchi MC, Annals of the Romanian Society for Cell Biology 20 35-39. 2015.

Effects of 17- β estradiol in a novel co- culture system of human Wharton’s jelly-derived mesenchymal stem cells with adult- heart murine ventricular slices on cardiac regeneration. Corotchi MC* & Popa MA*, Atherosclerosis 241 e93. (*equal contribution), 2015, IF:3.942

2014

Molecular characterization of staphylococcus aureus strains isolated from infective endocarditis, Oprea, M., Patriche DS, Străuţ M, Antohe F, Volume 73, Issue 3-4, 1 July 2014, Pages 74-83, Roumanian archives of microbiology and immunology 2014

National and International Grants (2014-2024)

2023–2026: PNRR-III-C9-2022–I8: CF 760061/23.05.023: Development of a new immunomodulatory therapy to reduce cardiac inflammation in myocardial infarction, myocarditis, and sepsis; https://www.icbp.ro/static/en/en-networking_grants-grants/pnrr.html

2022–2024: PN-III-P4-PCE-2021-1344, Contract number: PCE 114/2022: Molecular markers for prediction of evolution and prognosis in diabetic foot management, Acronym: DIAMARK; https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/diamark.html

2022-2024: PN-III-P1-1.1-TE-2021-1161: Circulating chaperone molecules in blood – potential predictors of gestational diabetes evolution; a proteomic analysis; https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/pregdm.html

2018-2022: PN-III-P4-ID-PCCF-2016-0172: Targeting innate immunity mechanisms for better risk stratification and identification of new therapeutic options in myocardial infarction, INNATE-IM; https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/innatemi.html

2018-2020: PNIII-P1-1.1-PD-2016-1369: Dynamics of endothelial junctional proteins in HMGB1-induced angiogenesis; Clinical implications. https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/epangio.html

2020-2021: PN-III-P1-1.1-PD2019-1234, Contract with No. PD160 / 2020, The role of the interaction between mesenchymal stromal cells and fibroblasts in the modulation of cardiac fibrosis by matrix metalloproteinase CD147; https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/fibrostem.html

2018-2021: XploreCAD; ERA-NET on Cardiovascular Diseases: Advanced ex vivo analyses and multi-frequency ultrasound technology for improved evaluation and diagnosis of coronary plaque (ERA-CVD Contract 41/2018); https://www.icbp.ro/static/en/en-networking_grants-grants-international/xplorecad.html

2015-2018: Norway Research Council - FRIPRO program: Multifunctional microbubbles for improved image-based diagnosis and drug delivery; https://www.sintef.no/en/projects/2015/multibubble/

2012-2016: PN-II-PCCA-2011-3: Fabrication of osteoinductive orthopedic implants with a hierarchical 3D gradient structure (FABIO3D); https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/fabio3d.html

2012-2016: PNII-PT-PCCA 2011-3, (CF 135/2012): Molecular markers as predictors of post-therapeutic evolution and prognosis in the management of differentiated thyroid carcinoma (GENITIR); https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/diamark.html

2012-2016: PN-II-PT-PCCA-2011-3.2-1490:The role of S100A4 and MAP4K4 in the progression of pancreatic ductal adenocarcinoma; S100MAP https://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/s100map.html